Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age
Identifieur interne : 000853 ( Main/Exploration ); précédent : 000852; suivant : 000854Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age
Auteurs : John Tesser [États-Unis] ; Shelly Kafka [États-Unis] ; Raphael J. Dehoratius [États-Unis] ; Stephen Xu [États-Unis] ; Elizabeth C. Hsia [États-Unis] ; Anthony Turkiewicz [États-Unis]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2019.
Abstract
To evaluate the safety and efficacy of intravenous golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) aged < 65 years and those ≥ 65 years who were enrolled in the GO-FURTHER study.
In the phase III, double-blind, randomized, placebo-controlled GO-FURTHER trial, patients with active RA were randomized to intravenous (IV) golimumab 2 mg/kg + MTX or placebo + MTX at weeks 0 and 4, then every 8 weeks thereafter (with crossover to golimumab at week 16 [early escape] or week 24 [per-protocol]). The final golimumab infusion was at week 100. Assessments included American College of Rheumatology (ACR) 20/50/70 response criteria. Efficacy and adverse events (AEs) were monitored through 2 years. Efficacy and AEs were summarized for patients aged < 65 years or ≥ 65 years; AEs were also summarized for patients < or ≥ 70 years and patients < or ≥ 75 years.
In GO-FURTHER, 592 patients were randomized to receive placebo (
In GO-FURTHER, ACR response rates were similar between patients < 65 years and patients ≥ 65 years within each treatment group. AEs in elderly patients were similar to the known safety profile of IV golimumab. Immunosenescence is known to increase the risk of infections in the elderly. Elderly patients had a numerically higher incidence of serious infections. Six malignancies occurred in golimumab-treated patients, all in patients < 65 years.
clinicaltrials.gov:
Url:
DOI: 10.1186/s13075-019-1968-x
PubMed: 31429794
PubMed Central: 6701065
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000030
- to stream Pmc, to step Curation: 000030
- to stream Pmc, to step Checkpoint: 000794
- to stream Ncbi, to step Merge: 000944
- to stream Ncbi, to step Curation: 000944
- to stream Ncbi, to step Checkpoint: 000944
- to stream Main, to step Merge: 000853
- to stream Main, to step Curation: 000853
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age</title><author><name sortKey="Tesser, John" sort="Tesser, John" uniqKey="Tesser J" first="John" last="Tesser">John Tesser</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Arizona Arthritis and Rheumatology Associates, Phoenix, AZ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Arizona Arthritis and Rheumatology Associates, Phoenix</wicri:cityArea></affiliation></author><author><name sortKey="Kafka, Shelly" sort="Kafka, Shelly" uniqKey="Kafka S" first="Shelly" last="Kafka">Shelly Kafka</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Scientific Affairs, LLC,</institution></institution-wrap>Horsham, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Horsham</wicri:cityArea></affiliation></author><author><name sortKey="Dehoratius, Raphael J" sort="Dehoratius, Raphael J" uniqKey="Dehoratius R" first="Raphael J." last="Dehoratius">Raphael J. Dehoratius</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Scientific Affairs, LLC,</institution></institution-wrap>Horsham, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Horsham</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id><institution-id institution-id-type="GRID">grid.265008.9</institution-id><institution>Sidney Kimmel School of Medicine,</institution><institution>Thomas Jefferson University,</institution></institution-wrap>Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Stephen" sort="Xu, Stephen" uniqKey="Xu S" first="Stephen" last="Xu">Stephen Xu</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Research & Development, LLC,</institution></institution-wrap>Spring House, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Spring House</wicri:cityArea></affiliation></author><author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Research & Development, LLC,</institution></institution-wrap>Spring House, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Spring House</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8972</institution-id><institution-id institution-id-type="GRID">grid.25879.31</institution-id><institution>University of Pennsylvania,</institution></institution-wrap>Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Turkiewicz, Anthony" sort="Turkiewicz, Anthony" uniqKey="Turkiewicz A" first="Anthony" last="Turkiewicz">Anthony Turkiewicz</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Rheumatology Associates, Birmingham, AL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Rheumatology Associates, Birmingham</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31429794</idno><idno type="pmc">6701065</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701065</idno><idno type="RBID">PMC:6701065</idno><idno type="doi">10.1186/s13075-019-1968-x</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000030</idno><idno type="wicri:Area/Pmc/Curation">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000030</idno><idno type="wicri:Area/Pmc/Checkpoint">000794</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000794</idno><idno type="wicri:Area/Ncbi/Merge">000944</idno><idno type="wicri:Area/Ncbi/Curation">000944</idno><idno type="wicri:Area/Ncbi/Checkpoint">000944</idno><idno type="wicri:doubleKey">1478-6354:2019:Tesser J:efficacy:and:safety</idno><idno type="wicri:Area/Main/Merge">000853</idno><idno type="wicri:Area/Main/Curation">000853</idno><idno type="wicri:Area/Main/Exploration">000853</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age</title><author><name sortKey="Tesser, John" sort="Tesser, John" uniqKey="Tesser J" first="John" last="Tesser">John Tesser</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Arizona Arthritis and Rheumatology Associates, Phoenix, AZ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Arizona Arthritis and Rheumatology Associates, Phoenix</wicri:cityArea></affiliation></author><author><name sortKey="Kafka, Shelly" sort="Kafka, Shelly" uniqKey="Kafka S" first="Shelly" last="Kafka">Shelly Kafka</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Scientific Affairs, LLC,</institution></institution-wrap>Horsham, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Horsham</wicri:cityArea></affiliation></author><author><name sortKey="Dehoratius, Raphael J" sort="Dehoratius, Raphael J" uniqKey="Dehoratius R" first="Raphael J." last="Dehoratius">Raphael J. Dehoratius</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Scientific Affairs, LLC,</institution></institution-wrap>Horsham, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Horsham</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2166 5843</institution-id><institution-id institution-id-type="GRID">grid.265008.9</institution-id><institution>Sidney Kimmel School of Medicine,</institution><institution>Thomas Jefferson University,</institution></institution-wrap>Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Stephen" sort="Xu, Stephen" uniqKey="Xu S" first="Stephen" last="Xu">Stephen Xu</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Research & Development, LLC,</institution></institution-wrap>Spring House, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Spring House</wicri:cityArea></affiliation></author><author><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4927</institution-id><institution-id institution-id-type="GRID">grid.497530.c</institution-id><institution>Janssen Research & Development, LLC,</institution></institution-wrap>Spring House, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Spring House</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8972</institution-id><institution-id institution-id-type="GRID">grid.25879.31</institution-id><institution>University of Pennsylvania,</institution></institution-wrap>Philadelphia, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Turkiewicz, Anthony" sort="Turkiewicz, Anthony" uniqKey="Turkiewicz A" first="Anthony" last="Turkiewicz">Anthony Turkiewicz</name><affiliation wicri:level="2"><nlm:aff id="Aff6">Rheumatology Associates, Birmingham, AL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Rheumatology Associates, Birmingham</wicri:cityArea></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p id="Par1">To evaluate the safety and efficacy of intravenous golimumab + methotrexate (MTX) in patients with active rheumatoid arthritis (RA) aged < 65 years and those ≥ 65 years who were enrolled in the GO-FURTHER study.</p></sec><sec><title>Methods</title><p id="Par2">In the phase III, double-blind, randomized, placebo-controlled GO-FURTHER trial, patients with active RA were randomized to intravenous (IV) golimumab 2 mg/kg + MTX or placebo + MTX at weeks 0 and 4, then every 8 weeks thereafter (with crossover to golimumab at week 16 [early escape] or week 24 [per-protocol]). The final golimumab infusion was at week 100. Assessments included American College of Rheumatology (ACR) 20/50/70 response criteria. Efficacy and adverse events (AEs) were monitored through 2 years. Efficacy and AEs were summarized for patients aged < 65 years or ≥ 65 years; AEs were also summarized for patients < or ≥ 70 years and patients < or ≥ 75 years.</p></sec><sec><title>Results</title><p id="Par3">In GO-FURTHER, 592 patients were randomized to receive placebo (<italic>n</italic> = 197) or golimumab (<italic>n</italic> = 395), 515 were aged < 65 years and 77 were ≥ 65 years. At week 24, ACR20 response rates were greater for golimumab + MTX patients compared with placebo + MTX for patients < 65 years (61.6% vs 31.3%, <italic>p</italic> < 0.001) and those ≥ 65 years (69.5% vs 33.3%; <italic>p</italic> < 0.01). Infections were the most common AE through week 112 (51.6% in patients < 65 years; 55.3% in patients ≥ 65 years); upper respiratory infections were the most common infection in patients < 65 years (13.2%) and those ≥ 65 years (11.8%). Serious AEs occurred in 17.7% in patients < 65 years and 25.0% of patients ≥ 65 years and included malignancies, pneumonia, fractures, acute pancreatitis, cellulitis, and bacterial arthritis.</p></sec><sec><title>Conclusions</title><p id="Par4">In GO-FURTHER, ACR response rates were similar between patients < 65 years and patients ≥ 65 years within each treatment group. AEs in elderly patients were similar to the known safety profile of IV golimumab. Immunosenescence is known to increase the risk of infections in the elderly. Elderly patients had a numerically higher incidence of serious infections. Six malignancies occurred in golimumab-treated patients, all in patients < 65 years.</p></sec><sec><title>Trial registration</title><p id="Par5">clinicaltrials.gov: <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/study/NCT00973479?term=NCT00973479&rank=1">NCT00973479</ext-link>. Registered September 9, 2009.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author><author><name sortKey="Fleischmann, Rm" uniqKey="Fleischmann R">RM Fleischmann</name></author><author><name sortKey="Strusberg, I" uniqKey="Strusberg I">I Strusberg</name></author><author><name sortKey="Durez, P" uniqKey="Durez P">P Durez</name></author><author><name sortKey="Nash, P" uniqKey="Nash P">P Nash</name></author><author><name sortKey="Amante, Ej" uniqKey="Amante E">EJ Amante</name></author><author><name sortKey="Churchill, M" uniqKey="Churchill M">M Churchill</name></author><author><name sortKey="Park, W" uniqKey="Park W">W Park</name></author><author><name sortKey="Pons Estel, B" uniqKey="Pons Estel B">B Pons-Estel</name></author><author><name sortKey="Han, C" uniqKey="Han C">C Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keystone, Ec" uniqKey="Keystone E">EC Keystone</name></author><author><name sortKey="Genovese, Mc" uniqKey="Genovese M">MC Genovese</name></author><author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name></author><author><name sortKey="Bae, Sc" uniqKey="Bae S">SC Bae</name></author><author><name sortKey="Han, C" uniqKey="Han C">C Han</name></author><author><name sortKey="Gathany, Ta" uniqKey="Gathany T">TA Gathany</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S Xu</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Leu, Jh" uniqKey="Leu J">JH Leu</name></author><author><name sortKey="Hsia, Ec" uniqKey="Hsia E">EC Hsia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Kay, J" uniqKey="Kay J">J Kay</name></author><author><name sortKey="Landewe, Rbm" uniqKey="Landewe R">RBM Landewe</name></author><author><name sortKey="Matteson, El" uniqKey="Matteson E">EL Matteson</name></author><author><name sortKey="Gaylis, N" uniqKey="Gaylis N">N Gaylis</name></author><author><name sortKey="Wollenhaupt, J" uniqKey="Wollenhaupt J">J Wollenhaupt</name></author><author><name sortKey="Murphy, Ft" uniqKey="Murphy F">FT Murphy</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Hsia, Ec" uniqKey="Hsia E">EC Hsia</name></author><author><name sortKey="Doyle, Mk" uniqKey="Doyle M">MK Doyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kavanaugh, A" uniqKey="Kavanaugh A">A Kavanaugh</name></author><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name></author><author><name sortKey="Mease, P" uniqKey="Mease P">P Mease</name></author><author><name sortKey="Krueger, Gg" uniqKey="Krueger G">GG Krueger</name></author><author><name sortKey="Gladman, D" uniqKey="Gladman D">D Gladman</name></author><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name></author><author><name sortKey="Leu, Jh" uniqKey="Leu J">JH Leu</name></author><author><name sortKey="Goldstein, N" uniqKey="Goldstein N">N Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deodhar, A" uniqKey="Deodhar A">A Deodhar</name></author><author><name sortKey="Braun, J" uniqKey="Braun J">J Braun</name></author><author><name sortKey="Inman, Rd" uniqKey="Inman R">RD Inman</name></author><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S Xu</name></author><author><name sortKey="Han, C" uniqKey="Han C">C Han</name></author><author><name sortKey="Hsu, B" uniqKey="Hsu B">B Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandborn, Wj" uniqKey="Sandborn W">WJ Sandborn</name></author><author><name sortKey="Feagan, Bg" uniqKey="Feagan B">BG Feagan</name></author><author><name sortKey="Marano, C" uniqKey="Marano C">C Marano</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Strauss, R" uniqKey="Strauss R">R Strauss</name></author><author><name sortKey="Johanns, J" uniqKey="Johanns J">J Johanns</name></author><author><name sortKey="Adedokun, Oj" uniqKey="Adedokun O">OJ Adedokun</name></author><author><name sortKey="Guzzo, C" uniqKey="Guzzo C">C Guzzo</name></author><author><name sortKey="Colombel, Jf" uniqKey="Colombel J">JF Colombel</name></author><author><name sortKey="Reinisch, W" uniqKey="Reinisch W">W Reinisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bingham, Clifton O" uniqKey="Bingham C">Clifton O. Bingham</name></author><author><name sortKey="Mendelsohn, Alan M" uniqKey="Mendelsohn A">Alan M. Mendelsohn</name></author><author><name sortKey="Kim, Lilianne" uniqKey="Kim L">Lilianne Kim</name></author><author><name sortKey="Xu, Zhenhua" uniqKey="Xu Z">Zhenhua Xu</name></author><author><name sortKey="Leu, Jocelyn" uniqKey="Leu J">Jocelyn Leu</name></author><author><name sortKey="Han, Chenglong" uniqKey="Han C">Chenglong Han</name></author><author><name sortKey="Lo, Kim Hung" uniqKey="Lo K">Kim Hung Lo</name></author><author><name sortKey="Westhovens, Rene" uniqKey="Westhovens R">Rene Westhovens</name></author><author><name sortKey="Weinblatt, Michael E" uniqKey="Weinblatt M">Michael E. Weinblatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kavanaugh, A" uniqKey="Kavanaugh A">A Kavanaugh</name></author><author><name sortKey="Husni, Me" uniqKey="Husni M">ME Husni</name></author><author><name sortKey="Harrison, Dd" uniqKey="Harrison D">DD Harrison</name></author><author><name sortKey="Kim, L" uniqKey="Kim L">L Kim</name></author><author><name sortKey="Lo, Kh" uniqKey="Lo K">KH Lo</name></author><author><name sortKey="Leu, Jh" uniqKey="Leu J">JH Leu</name></author><author><name sortKey="Hsia, Ec" uniqKey="Hsia E">EC Hsia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deodhar, A" uniqKey="Deodhar A">A Deodhar</name></author><author><name sortKey="Reveille, Jd" uniqKey="Reveille J">JD Reveille</name></author><author><name sortKey="Harrison, Dd" uniqKey="Harrison D">DD Harrison</name></author><author><name sortKey="Kim, L" uniqKey="Kim L">L Kim</name></author><author><name sortKey="Lo, Kh" uniqKey="Lo K">KH Lo</name></author><author><name sortKey="Leu, Jh" uniqKey="Leu J">JH Leu</name></author><author><name sortKey="Hsia, Ec" uniqKey="Hsia E">EC Hsia</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schneeweiss, S" uniqKey="Schneeweiss S">S Schneeweiss</name></author><author><name sortKey="Setoguchi, S" uniqKey="Setoguchi S">S Setoguchi</name></author><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Katz, Jn" uniqKey="Katz J">JN Katz</name></author><author><name sortKey="Avorn, J" uniqKey="Avorn J">J Avorn</name></author><author><name sortKey="Sax, Pe" uniqKey="Sax P">PE Sax</name></author><author><name sortKey="Levin, R" uniqKey="Levin R">R Levin</name></author><author><name sortKey="Solomon, Dh" uniqKey="Solomon D">DH Solomon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, Sk" uniqKey="Cho S">SK Cho</name></author><author><name sortKey="Sung, Yk" uniqKey="Sung Y">YK Sung</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name></author><author><name sortKey="Won, S" uniqKey="Won S">S Won</name></author><author><name sortKey="Choi, Cb" uniqKey="Choi C">CB Choi</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Jun, Jb" uniqKey="Jun J">JB Jun</name></author><author><name sortKey="Yoo, Dh" uniqKey="Yoo D">DH Yoo</name></author><author><name sortKey="Bae, Sc" uniqKey="Bae S">SC Bae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bathon, Jm" uniqKey="Bathon J">JM Bathon</name></author><author><name sortKey="Fleischmann, Rm" uniqKey="Fleischmann R">RM Fleischmann</name></author><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D Van der Heijde</name></author><author><name sortKey="Tesser, Jr" uniqKey="Tesser J">JR Tesser</name></author><author><name sortKey="Peloso, Pm" uniqKey="Peloso P">PM Peloso</name></author><author><name sortKey="Chon, Y" uniqKey="Chon Y">Y Chon</name></author><author><name sortKey="White, B" uniqKey="White B">B White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Bingham, Co" uniqKey="Bingham C">CO Bingham</name></author><author><name sortKey="Mendelsohn, Am" uniqKey="Mendelsohn A">AM Mendelsohn</name></author><author><name sortKey="Kim, L" uniqKey="Kim L">L Kim</name></author><author><name sortKey="Mack, M" uniqKey="Mack M">M Mack</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D Baker</name></author><author><name sortKey="Westhovens, R" uniqKey="Westhovens R">R Westhovens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fries, Jf" uniqKey="Fries J">JF Fries</name></author><author><name sortKey="Spitz, P" uniqKey="Spitz P">P Spitz</name></author><author><name sortKey="Kraines, Rg" uniqKey="Kraines R">RG Kraines</name></author><author><name sortKey="Holman, Hr" uniqKey="Holman H">HR Holman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, Je" uniqKey="Ware J">JE Ware</name></author><author><name sortKey="Sherbourne, Cd" uniqKey="Sherbourne C">CD Sherbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, T" uniqKey="Ali T">T Ali</name></author><author><name sortKey="Kaitha, S" uniqKey="Kaitha S">S Kaitha</name></author><author><name sortKey="Mahmood, S" uniqKey="Mahmood S">S Mahmood</name></author><author><name sortKey="Ftesi, A" uniqKey="Ftesi A">A Ftesi</name></author><author><name sortKey="Stone, J" uniqKey="Stone J">J Stone</name></author><author><name sortKey="Bronze, Ms" uniqKey="Bronze M">MS Bronze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smitten, Al" uniqKey="Smitten A">AL Smitten</name></author><author><name sortKey="Simon, Ta" uniqKey="Simon T">TA Simon</name></author><author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name></author><author><name sortKey="Suissa, S" uniqKey="Suissa S">S Suissa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pawelec, G" uniqKey="Pawelec G">G Pawelec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castle, Sc" uniqKey="Castle S">SC Castle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murota, A" uniqKey="Murota A">A Murota</name></author><author><name sortKey="Kaneko, Y" uniqKey="Kaneko Y">Y Kaneko</name></author><author><name sortKey="Yamaoka, K" uniqKey="Yamaoka K">K Yamaoka</name></author><author><name sortKey="Takeuchi, T" uniqKey="Takeuchi T">T Takeuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galloway, Jb" uniqKey="Galloway J">JB Galloway</name></author><author><name sortKey="Hyrich, Kl" uniqKey="Hyrich K">KL Hyrich</name></author><author><name sortKey="Mercer, Lk" uniqKey="Mercer L">LK Mercer</name></author><author><name sortKey="Dixon, Wg" uniqKey="Dixon W">WG Dixon</name></author><author><name sortKey="Fu, B" uniqKey="Fu B">B Fu</name></author><author><name sortKey="Ustianowski, Ap" uniqKey="Ustianowski A">AP Ustianowski</name></author><author><name sortKey="Watson, Kd" uniqKey="Watson K">KD Watson</name></author><author><name sortKey="Lunt, M" uniqKey="Lunt M">M Lunt</name></author><author><name sortKey="Symmons, Dp" uniqKey="Symmons D">DP Symmons</name></author><author><name sortKey="Consortium, Bcc" uniqKey="Consortium B">BCC Consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curtis, Jr" uniqKey="Curtis J">JR Curtis</name></author><author><name sortKey="Schulze Koops, H" uniqKey="Schulze Koops H">H Schulze-Koops</name></author><author><name sortKey="Takiya, L" uniqKey="Takiya L">L Takiya</name></author><author><name sortKey="Mebus, Ca" uniqKey="Mebus C">CA Mebus</name></author><author><name sortKey="Terry, Kk" uniqKey="Terry K">KK Terry</name></author><author><name sortKey="Biswas, P" uniqKey="Biswas P">P Biswas</name></author><author><name sortKey="Jones, Tv" uniqKey="Jones T">TV Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleischmann, R" uniqKey="Fleischmann R">R Fleischmann</name></author><author><name sortKey="Alam, J" uniqKey="Alam J">J Alam</name></author><author><name sortKey="Arora, V" uniqKey="Arora V">V Arora</name></author><author><name sortKey="Bradley, J" uniqKey="Bradley J">J Bradley</name></author><author><name sortKey="Schlichting, De" uniqKey="Schlichting D">DE Schlichting</name></author><author><name sortKey="Muram, D" uniqKey="Muram D">D Muram</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brassard, P" uniqKey="Brassard P">P Brassard</name></author><author><name sortKey="Bitton, A" uniqKey="Bitton A">A Bitton</name></author><author><name sortKey="Suissa, A" uniqKey="Suissa A">A Suissa</name></author><author><name sortKey="Sinyavskaya, L" uniqKey="Sinyavskaya L">L Sinyavskaya</name></author><author><name sortKey="Patenaude, V" uniqKey="Patenaude V">V Patenaude</name></author><author><name sortKey="Suissa, S" uniqKey="Suissa S">S Suissa</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Arizona</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Tesser, John" sort="Tesser, John" uniqKey="Tesser J" first="John" last="Tesser">John Tesser</name></region><name sortKey="Dehoratius, Raphael J" sort="Dehoratius, Raphael J" uniqKey="Dehoratius R" first="Raphael J." last="Dehoratius">Raphael J. Dehoratius</name><name sortKey="Dehoratius, Raphael J" sort="Dehoratius, Raphael J" uniqKey="Dehoratius R" first="Raphael J." last="Dehoratius">Raphael J. Dehoratius</name><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name><name sortKey="Hsia, Elizabeth C" sort="Hsia, Elizabeth C" uniqKey="Hsia E" first="Elizabeth C." last="Hsia">Elizabeth C. Hsia</name><name sortKey="Kafka, Shelly" sort="Kafka, Shelly" uniqKey="Kafka S" first="Shelly" last="Kafka">Shelly Kafka</name><name sortKey="Turkiewicz, Anthony" sort="Turkiewicz, Anthony" uniqKey="Turkiewicz A" first="Anthony" last="Turkiewicz">Anthony Turkiewicz</name><name sortKey="Xu, Stephen" sort="Xu, Stephen" uniqKey="Xu S" first="Stephen" last="Xu">Stephen Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000853 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000853 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6701065
|texte= Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31429794" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |